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KMID : 0361520070180020086
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Korean Journal of Psychopharmacology
2007 Volume.18 No. 2 p.86 ~ p.91
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Two-Year Rehospitalization Rates of First Episode Schizophrenic Inpatients Discharged on Antipsychotic Medication：A Preliminary Study
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Woo Young-Sup
Yook Dong-Hyun
Seo Ho-Jun
Chae Jeong-Ho
Jun Tae-Youn
Bahk Won-Myong
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Abstract
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Objective：We compared the rehospitalization rate of first-episode schizophrenic inpatients who were discharged from a university hospital while being treated with risperidone, olanzapine, quetiapine, or the conventional antipsychotic haloperidol. We also assessed other possible predictors of rehospitalization.
Methods：We monitored the rehospitalization status of all first-episode schizophrenic inpatients who were discharged from a university hospital between 1 January 2001 and 30 June 2003 while they were taking risperidone (n=16), olanzapine (n=26), quetiapine (n=9), or haloperidol (n=10). Rehospitalizations were tracked over a 2-year period using the Kaplan- Meier method. Risk factors associated with rehospitalization were examined using the Cox proportional hazards regression model.
Results：The rehospitalization rates estimated using the Kaplan-Meier formula for patients taking haloperidol (60.0%) did not differ significantly from the rates for patients treated with risperidone (37.5%), olanzapine (34.6%), or quetiapine (33.3%) during the 24-month follow-up period. The length of untreated illness before drug treatment predicted rehospitalization.
Conclusion：The rehospitalization rates of first-episode schizophrenic inpatients taking risperidone, olanzapine, quetiapine, or haloperidol do not differ. However, the small number of patients who participated in this study made it difficult to establish significance.
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KEYWORD
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Schizophrenia, Antipsychotics, Rehospitalization rate
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